Application of single-cell RNA-seq technology in the auxiliary diagnosis and treatment of esophageal squamous cell carcinoma

VernacularTitle:单细胞RNA测序技术在食管鳞状细胞癌辅助诊疗中的应用
Author: Guangyu XIANG ¹ ; Jiahe LI ; Gang JI ; Xin GUO ; Qiang LU
Author Information

1. 空军军医大学基础医学院，西安　710032
Keywords: Esophageal neoplasms; Neoplasms, squamous cell; Sequence analysis, RNA
From: Journal of International Oncology 2022;49(12):745-748
CountryChina
Language:Chinese
Abstract: Single-cell RNA-seq (scRNA-seq) can describe the changes of gene expression in a single tumor cell. And it can reveal the status and function of tumor cells, and capture the extensive transcriptome heterogeneity in the cell population. The application of scRNA-seq can monitor the specific highly expressed genes in esophageal squamous cell carcinoma (ESCC) , and it can also monitor genes related to radio chemotherapy resistance in tumor cells, which is helpful to provide more accurate auxiliary diagnosis for ESCC. Besides, scRNA-seq can evaluate the recurrence risk and survival time of patients. An in-depth study of the relationship between tumor cells and tumor microenvironment in ESCC will provide a theoretical basis for developing a new immunotherapy scheme for ESCC.