Research progress of liquid biopsy in the diagnosis and treatment of hepatocellular carcinoma

VernacularTitle:液体活检在原发性肝癌诊治中的研究进展
Author: Cong CHU ¹ ; Lei SHEN ; Wei WEI ; Yechuan XU
Author Information

1. 安徽医科大学第一附属医院肝胆胰外科，合肥　230022
Keywords: Liver neoplasms; Diagnosis; Therapeutic uses; Hepatocellular carcinoma; Liquid biopsy
From: International Journal of Surgery 2023;50(8):572-576
CountryChina
Language:Chinese
Abstract: Liver cancer is the second largest cancer in China, with the majority being hepatocellular carcinoma(HCC), which has a significant adverse impact on the lives and health of the Chinese people. Liquid biopsy is a new type of examination method with peripheral blood as the main examination subject. Compared with conventional tumor tissue pathology, liquid biopsy has less trauma, and the detection items can more accurately represent a certain tumor tissue group, more directly reflect the biological behavior of tumor tissue in the patient′s body. It is widely used in tumor screening, staging and grading, tumor individualized treatment monitoring, and prognosis evaluation. The following is mainly about the diagnosis, therapeutic effect evaluation and prognosis prediction of liquid biopsy in HCC from three aspects: circulating tumor DNA (ctDNA), exosome and circulating tumor cells (CTC), and the challenges faced by liquid biopsy technology at present are briefly described and its future development is prospected.