Application and challenge of neoadjuvant immunotherapy on perioperative treatment for locally advanced gastric cancer
10.3760/cma.j.cn115396-20230301-00042
- VernacularTitle:新辅助免疫治疗在局部进展期胃癌外科治疗的应用现状与挑战
- Author:
Hao CUI
1
;
Kecheng ZHANG
;
Bo WEI
;
Lin CHEN
Author Information
1. 南开大学医学院，天津 300071
- Keywords:
Stomach neoplasms;
Neoadjuvant therapy;
Immunotherapy;
Surgery
- From:
International Journal of Surgery
2023;50(5):289-294
- CountryChina
- Language:Chinese
-
Abstract:
The application of immunotherapy in advanced gastric cancer has become a research hotspot. At the same time, the combination of immunotherapy and neoadjuvant therapy is expected to further achieve tumor downstage, pathological remission, increase the proportion of R0 resection, which enhance the overall therapeutic effect of locally advanced gastric cancer (LAGC). Whether neoadjuvant immunotherapy affects perioperative complications, adverse events, tumor pathological responses, and long-term survival in LAGC is still in the initial stage of clinical exploration, which depends on large-scale prospective phase III clinical studies to demonstrate its clinical value. Meanwhile, the application of new innovative drugs and comprehensive perioperative treatment, screening high-specific biomarkers for therapeutic prediction, and weighing the selection of neoadjuvant cycle and interval of treatment-operation time are helpful to optimize and standardize the rational application of neoadjuvant immunotherapy, and ultimately bring benefits to patients.
