Effect of lymph node metastasis on the prognosis of patients with G2 phase stage pancreatic neuroendocrine tumors
10.3760/cma.j.cn115396-20221130-00410
- VernacularTitle:淋巴结转移对G2期胰腺神经内分泌肿瘤患者预后的影响
- Author:
Xinxue ZHANG
1
;
Jun MA
;
Shaocheng LYU
;
Wenli XU
;
Jiantao KOU
;
Qiang HE
Author Information
1. 首都医科大学附属北京朝阳医院肝胆外科，北京 100020
- Keywords:
Endocrine gland neoplasms;
Neuroendocrine tumors;
Lymphatic metastasis;
Pancreatic neuroendocrine tumors
- From:
International Journal of Surgery
2023;50(4):236-240,F3
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of lymph node metastasis on the prognosis of patients with G2 phase stage pancreatic neuroendocrine neoplasm(pNEN).Methods:A retrospective case control study was conducted to analyze the case data of 368 patients with pancreatic neuroendocrine tumors in G2 phase stage from January 1, 2010 to December 31, 2016 in SEER database, including 174 males and 194 females. According to whether lymph nodes were metastatic, they are divided into lymph node non metastatic (N0) group ( n=272) and lymph node metastatic (N1) group ( n=96). The Kaplan-Meier method and Log-rank test were used to compare the overall survival rate (OS) of patients in the N0 and N1 groups. The COX proportional risk model was used to evaluate whether N stage was an independent risk factor affecting prognosis. Count data were expressed as cases and percentage(%), and Chi-square test was used for comparison between the groups. Results:Among all patients, the OS of patients in the N0 group was better than that of patients in the N1 group. The OS of N0 patients at 1, 3, and 5 years was 96.3%, 92.7%, and 85.6%, respectively, while the OS of N1 patients at 1, 3, and 5 years was 92.6%, 82.1%, and 82.1%, respectively ( P=0.014). Multivariate analysis showed that age ( HR=2.245, 95% CI: 1.126-4.475, P=0.022) and N stage ( HR=0.457, 95% CI: 0.237-0.883, P=0.020) were independent prognostic factors for G2 phase pNEN patients. Conclusion:Lymph node metastasis is one of the independent prognostic factors in patients with G2 phase stage pNEN.
