Effect of circRNA on breast cancer metastasis
10.3760/cma.j.cn115396-20230106-00005
- VernacularTitle:环状RNA对乳腺癌转移的影响
- Author:
Rongquan GONG
1
;
An XU
;
Deyuan FU
Author Information
1. 扬州大学医学院，扬州 225009
- Keywords:
Breast neoplasms;
Neoplasm metastasis;
Molecular biology;
Circular RNA
- From:
International Journal of Surgery
2023;50(2):108-114
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is the most common malignant tumor in women, and metastasis is the main cause of death in breast cancer patients. Circular RNA (circRNA) is prevalent, abundant in organisms, and are characterized by their stable structure, conserved sequences, and specific expression. CircRNA have emerged as crucial regulators in diverse human cancers including breast cancer. Increasing evidence suggests that circRNA are aberrantly expressed in tissues and cell lines of breast cancer and involved in breast cancer metastasis. However, systematic knowledge regarding circRNA involvement in metastatic breast cancer remains unclear. This review outline functional circRNA associated with breast cancer metastasis and discuss their underlying mechanisms, providing new ideas for early prediction, diagnosis and treatment of breast cancer metastasis in the future.
