Application and development of metagenomics next-generation sequencing technology in diagnosis of bone infection
10.3760/cma.j.cn115396-20220521-00175
- VernacularTitle:宏基因组学第二代测序技术在骨感染诊断中的应用及发展
- Author:
Yujie MA
1
;
Weikun HOU
;
Ke XU
;
Mingyi YANG
;
Xianjie WAN
;
Peng XU
Author Information
1. 西安交通大学附属红会医院骨坏死与关节重建科，西安 710054
- Keywords:
Infection;
Bone diseases, infectious;
Diagnosis;
Metagenomics next-generation sequencing
- From:
International Journal of Surgery
2022;49(11):780-784
- CountryChina
- Language:Chinese
-
Abstract:
Bone infection is a serious infectious disease in clinical practice due to its difficult treatment and poor prognosis. Therefore, early accurate diagnosis of bone infection is the key for successful treatment. The traditional detection methods is time consuming with lower positive rate. Therefore, it is urgent to find better detection techniques to identify the pathogenic microorganisms of bone infection. In recent years, metagenomic second-generation sequencing technology has been widely used in the diagnosis of clinical infectious diseases because of its advantages of accurate, rapid, efficient and comprehensive diagnosis of pathogenic microorganisms, and can be used as an effective tool for the diagnosis of bone infections. This paper mainly reviews the advantages, disadvantages and development direction of metagenomics next-generation sequencing technology in the diagnosis of bone infection.
