Research progress in culture, purification and isolation of synovial type A cells in vitro and their biological functions
10.3760/cma.j.cn121382-20230304-00415
- VernacularTitle:颞下颌关节滑膜A型细胞起源、体外培养、纯化分离及生物学功能的研究进展
- Author:
Cheng WAN
1
;
Yintao LEI
;
Keqiang WANG
Author Information
1. 山东第一医科大学第二附属医院口腔科，泰安 271000
- Keywords:
Synovial type-A cells;
Cell origin;
In vitro culture;
Purification and isolation;
Biological function
- From:
International Journal of Biomedical Engineering
2023;46(4):370-374
- CountryChina
- Language:Chinese
-
Abstract:
The temporomandibular joint (TMJ) is surrounded by a joint capsule, the smooth inner layer of which is called the synovial membrane. Synovium is involved in various intraarticular diseases, and it is a key area of joint disease. Synovial type-A cells are located in the lining layer of the synovial membrane, mostly on the side of the membrane close to the joint cavity. They have a strong phagocytic effect, and their main role is to remove the degradation products of the intra-articular and extracellular matrix. Various intra-articular diseases will affect the synovium, which is the key area of joint disease. The method of cell culture in vitro can effectively simulate the growth environment of cells in vivo and can accurately understand the effects of single and multiple factors on synovial cells, which has become a basic research method. In this review paper, the latest research progress in human temporomandibular joint type-A synoviocytes is reviewed from the aspects of cell origin, in vitro culture, cell purification, and cell biological function.
