Research progress in microRNA as a novel diagnostic marker for bone echinococcosis
10.3760/cma.j.cn121382-20230405-00414
- VernacularTitle:miRNA作为骨棘球蚴病诊断标志物的研究进展
- Author:
Liang LIN
1
;
Zengru XIE
Author Information
1. 宁波市海曙区第二医院骨科，宁波 315100
- Keywords:
MicroRNA;
Bone echinococcosis;
Echinococcus granulatus;
Echinococcus multilocularis;
Diagnostic markers
- From:
International Journal of Biomedical Engineering
2023;46(4):365-369
- CountryChina
- Language:Chinese
-
Abstract:
Bone echinococcosis is usually caused by Echinococcus granulosus and E. multilocularis. People become infected when they eat food or water contaminated with the eggs. Treatment of bone echinococcosis usually includes surgery and medication, but the lengthy and costly treatment imposes a heavy burden on patients. MicroRNAs (miRNA) are known to be involved in a variety of biological processes and host-host interactions, including development, cell growth and death, lifespan-related target regulation, transcription, signal transduction, and cell motility, which will help us find new strategies and targets for the treatment and control of osteonechoconiosis. For further understanding of bone echinococcosis, it is important to understand the molecular basis of E. multilocularis development in both final and intermediate hosts. The miRNA found in E. granulosus and E. multilocularis have gene and developmental stage specificity in their respective host expression regulation. In this review paper, the progress of research on miRNA as a novel diagnostic marker for osteoblastic echinococcosis is reviewed.
