Research progress in neutrophil-mediated delivery systems
10.3760/cma.j.cn121382-20230514-00411
- VernacularTitle:中性粒细胞介导的递送系统研究进展
- Author:
Xuya YU
1
;
Xia DONG
;
Feng LYU
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Neutrophil;
Drug delivery;
Targeted delivery;
Drug carrier
- From:
International Journal of Biomedical Engineering
2023;46(4):348-354
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophils are the first to reach the site of infection as they are the most numerous and dominant pathogen-killing cells in the circulatory system. They are both involved in initial immunity and act as effector cells in destructive inflammatory responses. The abundance of neutrophils in the human body and their inherent properties give them the ability to target inflammatory sites for drug delivery, and their important role in the inflammatory response has led to increasing attention to the therapeutic potential of neutrophils. In this review paper, the research progress in neutrophil-mediated drug delivery systems is reviewed, including the use of neutrophils as carriers, neutrophil exosomes as carriers, and in vivo targeted delivery of drugs using neutrophil properties.
