Research progress in quality research and evaluation of human mesenchymal stem cells
10.3760/cma.j.cn121382-20230411-00315
- VernacularTitle:人间充质干细胞质量研究及评价进展
- Author:
Yue SHI
1
;
Yan LI
;
Huifang JIN
;
Xinrui ZHAO
Author Information
1. 中源协和细胞基因工程股份有限公司，天津 300384
- Keywords:
Human mesenchymal stem cells;
Cell therapy;
Quality research;
Quality evaluation method
- From:
International Journal of Biomedical Engineering
2023;46(3):275-280
- CountryChina
- Language:Chinese
-
Abstract:
As adult stem cells, human mesenchymal stem cells (hMSCs) have the potential for self-replication, renewal, and multidirection differentiation. Their unique biological function determines their wide clinical indications. Researchers can define the quality attributes of hMSCs according to clinical expectations. The quality study of hMSCs should consider microbiological safety, biological safety, cell biological properties, and biological effectiveness. Quality evaluation is a common physical, chemical, and biological evaluation method for hMSCs. Traditional product safety evaluation strategies cannot fully adapt to current technology and product usage characteristics. Researchers have developed new, effective evaluation methods based on current technology. In terms of product efficacy evaluation strategies, an efficacy evaluation system has been gradually established and standardized according to the intended clinical use and based on quality studies, which can enable researchers to evaluate hMSCs products more comprehensively at different stages and processes. In this paper, the progress of quality research and evaluation of human mesenchymal stem cells was reviewed to provide a reference for the utilization of stem cells in the field of regenerative medicine.
