Research progress in the biological characteristics of matrix metalloproteinase-19 in tumor
10.3760/cma.j.cn121382-20221214-00313
- VernacularTitle:基质金属蛋白酶-19在肿瘤中生物学特性的研究进展
- Author:
Liming CHEN
1
;
Danlin WANG
;
Chunze ZHANG
;
Huajiang DONG
;
Zhihui TAI
;
Aidong LIU
Author Information
1. 天津市天津医院肛肠外科，天津 300211
- Keywords:
Matrix metalloproteinase-19;
Tumor;
Cell proliferation;
Cell adhesion;
Cell invasion;
Cell migration;
Cell angiogenesis
- From:
International Journal of Biomedical Engineering
2023;46(3):264-269
- CountryChina
- Language:Chinese
-
Abstract:
The matrix metalloproteinases family (MMPs) are proteins related to tumor formation and metastasis that have attracted the attention of scholars in recent years. Tumor cells can secrete MMPs during malignant transformation, and the expression of MMPs in different malignant tumors is diverse, and different members of MMPs do not have exactly the same biological properties. Matrix metalloproteinase-19 (MMP-19) is a new member of MMPs whose secretion increases rapidly during the malignant transformation of cells and is released into the extracellular space to participate in biological processes such as proliferation, adhesion, invasion, migration, and angiogenesis of tumor cells. In this paper, the progress of research on the biological properties of MMP-19 in tumors was reviewed to provide a theoretical basis for exploring the development of tumors, especially for studying the invasion and metastasis of tumor cells.
