Research progress of tRNA-derived fragments as biomarkers for diagnostic and prognostic assessment of tumors
10.3760/cma.j.cn121382-20230221-00311
- VernacularTitle:tRNA衍生片段作为肿瘤诊断性及预后评估生物标志物的研究进展
- Author:
Lingying ZHANG
1
;
Jiapaer ZEYIDAN
;
Chengyu LI
;
Shannan SONG
;
Yuyan ZHANG
;
Yongsheng LI
Author Information
1. 新疆大学生命科学与技术学院，新疆生物资源基因工程重点实验室，乌鲁木齐 830046
- Keywords:
Cancer;
tRNA-derived fragments;
Biomarkers;
Diagnosis;
Prognostic assessment
- From:
International Journal of Biomedical Engineering
2023;46(3):251-257
- CountryChina
- Language:Chinese
-
Abstract:
Cancer is the second-leading cause of death worldwide. Cancer mortality is largely caused by the absence of recognizable early signs and a poor prognosis. Therefore, developing efficient diagnostic and prognostic biomarkers is crucial to reducing the incidence of cancer and improving its prognostic accuracy. tRNA-derived fragments are a new class of non-coding RNAs with important regulatory roles in cancer biology. In this paper, the research progress of tRNA-derived fragments as biomarkers in tumorigenesis, development, and prognosis was reviewed to provide a theoretical basis for cancer diagnosis and prognostic assessment.
