Research progress in the application of CRISPR/Cas9 technology in the treatment of cervical cancer
10.3760/cma.j.cn121382-20221220-00209
- VernacularTitle:CRISPR/Cas9技术在宫颈癌治疗中的应用进展
- Author:
Yanan ZHAO
1
;
Aipire ADILA
;
Jinyao LI
Author Information
1. 新疆大学生命科学与技术学院，新疆生物资源基因工程重点实验室，乌鲁木齐 830046
- Keywords:
Cervical cancer;
CRISPR/Cas9 technology;
Gene editing
- From:
International Journal of Biomedical Engineering
2023;46(2):144-150
- CountryChina
- Language:Chinese
-
Abstract:
Cervical cancer is the fourth-ranked malignant tumor of female cancer in the world, and it seriously threatens women’s health. The main treatment options for patients with cervical cancer are surgery or concurrent chemoradiotherapy. With the development of medical research, researchers are committed to exploring more effective and specific treatment options in order to increase the treatment options for cervical cancer and improve the treatment effect. Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) technology is a method in which the Cas9 protein uses guide RNA (gRNA) to target the target gene and achieve precise editing of the target gene. At present, CRISPR/Cas9 technology has become a promising and powerful gene editing tool, a new and effective targeted therapy that has been applied in the treatment of various tumors. The research progress of CRISPR/Cas9 technology in the treatment of cervical cancer is mainly reviewed in terms of action targets, combination therapy strategies, and related drug resistance gene screening in order to provide new strategies for the treatment of cervical cancer.
