Genome-wide Association Study Identification of a New Genetic Locus with Susceptibility to Osteoporotic Fracture in the Korean Population.
- Author:
Joo Yeon HWANG
1
;
Seung Hun LEE
;
Min Jin GO
;
Beom Jun KIM
;
Young Jin KIM
;
Dong Joon KIM
;
Ji Hee OH
;
Heejo KOO
;
My Jung CHA
;
Min Hye LEE
;
Ji Young YUN
;
Hye Sook YOO
;
Young Ah KANG
;
Ki Won OH
;
Moo Il KANG
;
Ho Young SON
;
Shin Yoon KIM
;
Ghi Su KIM
;
Bok Ghee HAN
;
Yoon Shin CHO
;
Jung Min KOH
;
Jong Young LEE
Author Information
1. Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungbuk 363-951, Korea. leejy63@nih.go.kr
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
genomewide association study;
meta-analysis;
osteoporotic fracture;
intergenic
- MeSH:
Aged;
Bone Density;
Cohort Studies;
DNA, Intergenic;
Genetic Loci;
Genome-Wide Association Study;
Humans;
Osteoporosis;
Osteoporotic Fractures;
Risk Factors
- From:Genomics & Informatics
2011;9(2):52-58
- CountryRepublic of Korea
- Language:English
-
Abstract:
Osteoporotic fracture (OF), along with bone mineral density (BMD), is an important diagnostic parameter and a clinical predictive risk factor in the assessment of osteoporosis in the elderly population. However, a genomewide association study (GWAS) on OF has not yet been clarified sufficiently. To identify OF-associated genetic variants and candidate genes, we conducted a GWAS in a population-based cohort (Korean Association Resource [KARE], n=1,427 [case: 288 and control: 1139]) and performed a de novo replication study in hospital-based individuals (Asan and Catholic Medical Center [ACMC], n=1,082 [case: 272 and control: 810]). In a combined meta-analysis, a newly identified genetic locus in an intergenic region at 10p11.2 (near genes FZD8 and ANKRD30A ) showed the most significant association (odd ratio [OR] = 2.00, 95% confidence interval [CI] = 1.47~2.74, p=1.27x10(-5)) in the same direction. We provide the first evidence for a common genetic variant influencing OF and genetic information for further investigation in bone metabolism.
