Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study.
- Author:
Hae In LEE
1
;
Jae Jung KIM
;
Taesung PARK
;
Kyunga KIM
;
Jong Eun LEE
;
Yoon Shin CHO
;
Jong Young LEE
;
Bok Ghee HAN
;
Jong Keuk LEE
Author Information
1. Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea. cookie_jklee@hotmail.com
- Publication Type:Original Article
- Keywords:
genome-wide association study (GWAS);
body mass index (BMI);
Korean;
single nucleotide polymorphism (SNP)
- MeSH:
Adult;
Asian Continental Ancestry Group;
Body Mass Index;
Cardiovascular Diseases;
Cohort Studies;
Genetic Loci;
Genome-Wide Association Study;
Humans;
Obesity;
Receptor, Melanocortin, Type 4
- From:Genomics & Informatics
2011;9(2):59-63
- CountryRepublic of Korea
- Language:English
-
Abstract:
Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40~60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12, NFE2L3, MC4R and FTO) having p<1x10(-5). However, in the replication study, only melanocortin 4 receptor gene (MC4R) (rs9946888, p=4.58x10(-7)) was replicated with marginal significance (p<0.05) in the second cohort (n=5,102, age 40~60 years). This study indicates that each locus associated with BMI has very weak genetic effect.
