Research progress in the application of hybrid cell membrane biomimetic nano-drug delivery system in cancer treatment
10.3760/cma.j.cn121382-20221110-00113
- VernacularTitle:杂化细胞膜仿生纳米药物递送体系用于肿瘤治疗的研究进展
- Author:
Danhui HU
1
;
Mengyuan WANG
;
Keyi QU
;
Yongqi SHI
;
Guoyun WAN
;
Hongli CHEN
Author Information
1. 新乡医学院生命科学技术学院，生物医用材料重点实验室，新乡 453003
- Keywords:
Hybrid cell membrane;
Biomimetic nanoparticles;
Drug delivery;
Cancer treatment
- From:
International Journal of Biomedical Engineering
2023;46(1):74-79
- CountryChina
- Language:Chinese
-
Abstract:
The biomimetic strategy of using the cell membrane-coated nanoparticles can retain the physical and chemical properties of the nanoparticles and show the biological characteristics of the source cell membrane, which can further enhance the role of the nanodrug in tumor treatment. A hybrid cell membrane is the fusion of two or more different types of cell membranes. A hybrid cell membrane can endow nanoparticles with multiple biofunctions derived from the source cells compared with a single cell membrane. Hybrid cell membranes provide a foundation to stimulate extensive research into multifunctional biomimetic nano-drug delivery system (NDDS), which is expected to broaden the application of biomimetic nanotechnology in drug delivery systems. In this review paper, the types of hybrid cell membrane used to construct nano-drug delivery systems, the preparation and characterization methods, and cancer treatment research progress in recent years were reviewed.
