Correlation between serum 25-(OH)D 3, adiponectin, chemerin levels and insulin resistance in women with gestational diabetes
10.3760/cma.j.cn121382-20220708-00610
- VernacularTitle:25-（OH）D 3、脂联素、趋化素与妊娠期糖尿病患者胰岛素抵抗的相关性分析
- Author:
Xiaowen HAN
1
;
Zhen SUN
;
Xuejiao LI
;
Ya'nan ZHANG
;
Chengjin WANG
Author Information
1. 天津市中心妇产科医院药剂科，天津 300100
- Keywords:
25-(OH)D 3;
Adiponectin;
Chemerin;
Gestational diabetes mellitus;
Insulin resistance
- From:
International Journal of Biomedical Engineering
2022;45(6):527-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between the serum 25-(OH)D 3, adiponectin (APN), and chemerin levels of pregnant women with gestational diabetes mellitus (GDM) and insulin resistance. Methods:28 pregnant women with GDM were selected for the study group from May 2020 to December 2021, and 45 pregnant women with normal glucose tolerance were selected for the control group. 25-(OH)D 3, APN, chemerin, islet resistance index (HOMA-IR), fasting blood glucose, fasting insulin, and HbA1c were compared between the two groups. The correlation between 25-(OH)D 3, APN, chemerin, and GDM insulin resistance was analyzed. Results:Fasting blood glucose, fasting insulin, HOMA-IR, and chemerin in the GDM group were higher than those in the control group (all P<0.05), while 25-(OH)D 3 and APN were lower than those in the control group (all P<0.05). There was no statistical difference in HbA1c between the two groups. Logistic regression analysis showed that serum 25-(OH)D 3, APN, and chemerin were all related influencing factors of GDM (all P<0.05). Spearman's correlation analysis showed that serum 25-(OH)D 3 was negatively correlated with fasting blood glucose and HOMA-IR (all P<0.05), chemerin was positively correlated with fasting insulin and HOMA-IR (all P<0.05). ROC curve analysis showed that the AUC of 25-(OH)D 3 was 0.841 (95% CI: 0.746~0.967). AUC of APN was 0.678 (95% CI: 0.545~0.812). AUC of chemerin AUC was 0.360 (95% CI: 0.233~0.487). Conclusions:The levels of 25-(OH)D 3, APN, and chemerin have a certain correlation with the pathogenesis of GDM, which has a certain reference value for the prediction of GDM.
