Preparation and physicochemical properties of PVA/HA composite microspheres for embolization
10.3760/cma.j.cn121382-20220617-00607
- VernacularTitle:PVA/HA复合栓塞微球的制备与理化性能研究
- Author:
Yuexiong YANG
1
;
Jing LI
;
Xiaozhen XIAO
;
Xiaofeng ZHANG
;
Huachao DAI
;
Chao ZHANG
;
Xiaochun CHEN
;
Yang ZHANG
Author Information
1. 广州中大医疗器械有限公司，广州 510300
- Keywords:
Polyvinyl alcohol;
Hydroxyapatite;
Composite microspheres;
Reverse suspension polymerization;
Drug-loading performance;
Drug-releasing performance
- From:
International Journal of Biomedical Engineering
2022;45(6):508-514
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare polyvinyl alcohol (PVA) and hydroxyapatite (HA) composite embolization microspheres and investigate their physicochemical properties.Methods:PVA/HA composite embolization microspheres were prepared by reverse suspension polymerization, using PVA and HA as dispersed phases, liquid paraffin containing sorbitan fatty acid ester as the continuous phase, and glutaraldehyde as the cross-linking agent. The morphology, particle size distribution, and microscopic morphology of PVA/HA composite embolization microspheres were observed by optical microscopy and scanning electron microscopy. The chemical structure of PVA/HA composite embolization microspheres and the elasticity, drug loading, and drug release properties of PVA/HA composite bolus microspheres were characterized by Fourier infrared spectroscopy.Results:The PVA/HA composite embolization microspheres were internal, porous round spheres with a particle size distribution of 50-300 μm. The elastic properties of PVA/HA composite embolization microspheres were(13.6±0.145) kPa, which was 2.28 times that of PVA microspheres, and the drug loading capacity and encapsulation efficiency were (76.80±1.22) mg/g and (38.4±12.7)%, respectively. The maximum cumulative release rate of the microspheres within 7 days was (7.37±0.101)%, and the maximum cumulative release was (256.2±9.8) μg.Conclusions:PVA/HA composite embolization microspheres have good mechanical properties and drug-loading and drug-releasing properties, which provide an important reference for their use as medical devices.
