Research progress of androgen receptor signaling pathway in castration-resistant prostate cancer

VernacularTitle:雄激素受体信号通路在去势抵抗性前列腺癌中作用机制的研究进展
Author: Tuo YANG ¹ ; Keke CAI ; Bingxin LU
Author Information

1. 天津市南开医院泌尿外科，南开大学附属南开医院，天津市急腹症器官损伤与中西医修复重点实验室，天津　300102
Keywords: Androgen receptor; Signal pathway; Castration-resistant prostate cancer; Mechanism
From: International Journal of Biomedical Engineering 2022;45(5):458-461,467
CountryChina
Language:Chinese
Abstract: Prostate cancer is the most common male malignant tumor in the world, and its death toll is second only to lung cancer. Androgen deprivation therapy (ADT) is a major treatment for prostate cancer besides radical surgery. ADT treatment will lead to the inevitable progression of prostate cancer patients to castration-resistant prostate cancer (CRPC). The current research results have confirmed that the transformation from androgen deprivation prostate cancer (ADPC) to CRP is related to the reactivation of the androgen receptor signal pathway. In this review, the research progress on the mechanism of the androgen receptor signaling pathway in CRPC was reviewed in order to provide a scientific basis and new ideas for the diagnosis and treatment of CRP.