Research progress in research on platelets derived from induced pluripotent stem cells in vitro

VernacularTitle:人诱导多能干细胞来源血小板的研究进展
Author: Yuena XIE ¹ ; Jinghui CHONG ; Jun LIU ; Jinhui XIE ; Tongtong LI ; Tong PAN
Author Information

1. 天津市血液中心，天津　300110
Keywords: Human induced pluripotent stem cells; Platelets; Platelet products
From: International Journal of Biomedical Engineering 2022;45(5):448-452
CountryChina
Language:Chinese
Abstract: Currently, there are insufficient sources of platelets for clinical transfusion, and there are risks of alloimmune reactions and transfusion-transmitted infections (TTI) after transfusion. In recent years, platelets derived from human induced pluripotent stem cells (hiPSCs) have become one of the hottest research topics in the transfusion community, and studies have shown that they have the potential to address the limitations of platelet transfusion and alleviate the conflict between platelet supply and demand in clinical settings. However, the efficiency of hiPSCs in producing functional platelets in vitro is still low, and the yield and quality are still far below clinical transfusion standards. In this review, the basis and applications related to hiPSCs-derived platelets, studies related to human leukocyte antigen (HLA) gene-silenced hiPSC-derived platelets, and challenges faced by hiPSCs-derived platelet products were reviewed, providing references for in-depth research and future clinical applications of hiPSCs-derived platelets.