Research progress in cell signaling pathways regulating implant osseointegration
10.3760/cma.j.cn121382-20220612-00511
- VernacularTitle:调控种植体骨整合的细胞信号通路研究进展
- Author:
Xiaofei LV
1
;
Jie YANG
Author Information
1. 天津医科大学第二医院口腔科，天津 300211
- Keywords:
Implant;
Osseointegration;
Signal transduction
- From:
International Journal of Biomedical Engineering
2022;45(5):437-441,447
- CountryChina
- Language:Chinese
-
Abstract:
Dental implant restoration has become the preferred clinical option for the treatment of tooth loss. The basis for the functioning of implant prostheses is good osseointegration of the implant. Osteointegration is a delicate and complex biological process that is not only a simple physical attachment but also initiates and regulates a series of important events such as cell survival, migration, recruitment, and osteogenic differentiation, involving a series of physicochemical changes from the molecular to the cellular level. In-depth studies on osseointegration can facilitate the development of new implants, improve the success rate of implantation in complex clinical conditions, and have important implications for the prevention and treatment of peri-implant diseases. In this review, the research on the regulation of cell signal pathways of implant osseointegration was reviewed, including the biological process of implant osseointegration, integrin-mediated signal pathways, Wnt signal pathways, transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signal pathways, hypoxia-inducible factors (HIFs) signal pathways, Notch signal pathways, Hippo signal pathways, and other signal pathways related to bone integration that are expected to provide some theoretical reference for the optimization of implant performance.
