Research progress in the relationship between deubiquitinase OTUB1 and urological cancer
10.3760/cma.j.cn121382-20220221-00413
- VernacularTitle:去泛素化酶OTUB1与肿瘤相关性的研究现状
- Author:
Jianing GUO
1
;
Yihao LIAO
;
Yanchun QU
;
Enli LIANG
;
Hui LI
Author Information
1. 天津医科大学第二医院病理科，天津 300211
- Keywords:
Ovarian tumor associated proteinase B1;
Urological cancer;
Signal pathway
- From:
International Journal of Biomedical Engineering
2022;45(4):356-361,367
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian tumor-associated protease B1(OTUB1) is a member of the deubiquitinase family. Its highly specific recognition and cleavage function of polyubiquitinated chains has attracted widespread attention, and it can regulate a variety of important signaling pathways, such as the epithelial-mesenchymal transition (EMT) pathway, the MAPK signaling pathway, and the p53-related signaling pathway. In recent years, it has gradually become a new direction of oncology research. More and more studies have proved that OTUB1 is closely related to various tumors such as hepatocellular carcinoma, colorectal cancer, and breast cancer. It regulates the occurrence, development, and prognosis of tumors. OTUB1 could be a potential treatment for tumors. Urinary tract tumors mainly include prostate cancer, bladder cancer, and renal cell carcinoma. In this review, the research progress on the correlation between OTUB1 and urological tumors was reviewed, including its important role in the occurrence and development of urological tumors and the possibility of treating urological tumors with OTUB1.
