Research progress in antitumor and immunoregulation of fucoidan

VernacularTitle:褐藻糖胶抗肿瘤及免疫调节作用的研究进展
Author: Litong LIU ¹ ; Aipire ADILA ; Jinyao LI
Author Information

1. 新疆大学生命科学与技术学院，新疆生物资源基因工程重点实验室，乌鲁木齐　830046
Keywords: Fucoidan; Influence factor; Antitumor; Immunoregulation
From: International Journal of Biomedical Engineering 2022;45(4):321-327
CountryChina
Language:Chinese
Abstract: Fucoidan is a kind of sulfated polysaccharide with various biological activities that mainly exists in the cell walls of brown algae. It is also found in marine invertebrates such as sea cucumbers and sea urchins. Fucoidan has received a lot of attention due to its tumor-killing and immune-boosting properties. Moreover, the combination of fucoidan with chemotherapeutic drugs not only improves antitumor efficacy but also reduces the side effects of these drugs. The function of fucoidan is closely correlated with its structure, molecular weight, degree of sulfation, monosaccharide component, algae source, and time of collection. In this review, the antitumor and immunomodulatory effects of fucoidan are reviewed from the aspects of promoting cell apoptosis, inducing cell cycle arrest, inhibiting angiogenesis and cell migration, and activating immune cells, to provide theoretical guidance for the development and clinical application of fucoidan.