Changes of biomarkers in fluid derived from peritoneal cavity and their relationship with transport rate in peritoneum in patients with new peritoneal catheter
10.3760/cma.j.cn121382-20220305-00404
- VernacularTitle:腹膜透析患者腹透引出液中生物标志物的变化及其与腹膜转运速率的关系
- Author:
Na HAO
1
;
Zhiyuan XU
;
Haozhi TANG
;
Yajun QU
;
Wanwen LI
Author Information
1. 天津中医药大学第一附属医院肾病科，天津 300381
- Keywords:
New peritoneal catheter;
Peritoneal dialysis;
Fluid derived from peritoneal cavity;
Plasminogen activator inhibitor-1;
Matrix metalloproteinase-2;
Vascular
- From:
International Journal of Biomedical Engineering
2022;45(4):307-311
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of biomarkers in peritoneal dialysis patients' peritoneal drainage fluid and their relationship with the peritoneal small molecule solute transport rate (PSTR).Methods:Seventy newly-tubed peritoneal dialysis patients from the Peritoneal Dialysis Center of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from September 29, 2014 to April 26, 2018 were selected. The levels of biomarkers plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in the peritoneal dialysis priming fluid were measured at different time points and 4 h dialysate/blood muscle (D/P) creatinine values at 2 years of follow-up, and the correlation between biomarkers in the extracted peritoneal fluid and 4 h D/P creatinine was examined.Results:Longitudinal studies showed an increase in PAI-1 ( P<0.001) and VEGF ( P=0.04) with increasing duration of peritoneal dialysis. PSTR levels at baseline and after 2 years of follow-up were significantly correlated with PAI-1, MMP-2, and VEGF levels at baseline. PSTR at 2 years was also correlated with MMP-2 levels at 6 months and PAI-1 levels at baseline. Conclusions:The biomarkers PAI-1, MMP-2, and VEGF in peritoneal dialysis drainage fluid are positively correlated with PSTR in peritoneal dialysis patients during the 2-year period.
