Transcription factor EB attenuates neuronal damage following cerebral ischemia via regulating autophagy-lysosomal pathway
10.3760/cma.j.issn.1673-4165.2023.04.013
- VernacularTitle:转录因子EB调控自噬溶酶体通路减轻脑缺血后神经元损伤
- Author:
Dan LI
1
;
Xialin ZUO
;
En XU
Author Information
1. 广州医科大学神经科学研究所，广州医科大学附属第二医院神经内科，广州 510260
- Keywords:
Brain ischemia;
Basic helix-loop-helix leucine zipper transcription factors;
Autophagy;
Lysosomes;
Neuroprotective agents;
Signal transduction
- From:
International Journal of Cerebrovascular Diseases
2023;31(4):308-311
- CountryChina
- Language:Chinese
-
Abstract:
The disorder of autophagy lysosomal pathway (ALP) is an important pathogenesis of neuronal damage after cerebral ischemia, and the restoration of ALP may alleviate neuronal damage after cerebral ischemia. As the main transcription factor regulating ALP, transcription factor EB (TFEB) can directly regulate autophagosome generation, autophagosome-lysosome fusion, and autophagic flux by regulating the expression of autophagic genes and lysosomal genes. Therefore, regulating TFEB can alleviate ALP dysfunction and thereby reduce cerebral ischemic damage. This article reviews the structure, biological function of TFEB and its role in regulating ALP to alleviate neuronal damage after cerebral ischemia.
