Biological clock rhythm disorder and hypertension
10.3760/cma.j.issn.1673-4165.2023.04.012
- VernacularTitle:生物钟节律紊乱与高血压
- Author:
Luming LI
1
;
Haiyuan SHI
;
Ru LIU
;
Shayijun TAN
;
Mingli HE
Author Information
1. 徐州医科大学附属连云港医院，连云港市第一人民医院神经内科，连云港 222061
- Keywords:
CLOCK proteins;
Hypertension;
Blood pressure;
Stroke;
Circadian rhythm;
Period circadian proteins;
Gene expression regulation
- From:
International Journal of Cerebrovascular Diseases
2023;31(4):303-307
- CountryChina
- Language:Chinese
-
Abstract:
Biological clock proteins are involved in the regulation of many important physiological processes, including blood pressure. The deletion or mutation of core circadian clock genes may cause elevated blood pressure levels and disrupted blood pressure rhythms, exacerbating vascular function damage, and ultimately leading to the occurrence, development and poor outcome of ischemic stroke. This article reviews the molecular mechanism of biological clock rhythm, the relationship between biological clock gene and blood pressure regulation mechanism, the mechanism of circadian rhythm disorder in the occurrence and development of hypertension, and the relationship between blood pressure rhythm disorder and stroke.
