Role of homocysteinylation in cerebral atherosclerosis
10.3760/cma.j.issn.1673-4165.2023.04.011
- VernacularTitle:高半胱氨酸化在脑动脉粥样硬化中的作用
- Author:
Zhipeng GUO
1
;
Huakun LIU
;
Yanhong WANG
Author Information
1. 济宁医学院，济宁 272067
- Keywords:
Homocysteine;
Carotid artery diseases;
Atherosclerosis;
Intracranial arteriosclerosis;
Endothelium, vascular
- From:
International Journal of Cerebrovascular Diseases
2023;31(4):298-302
- CountryChina
- Language:Chinese
-
Abstract:
Homocysteine is closely associated with extracranial and intracranial atherosclerosis, and its main pathogenesis includes oxidative stress, lipid metabolism disorder and vascular endothelial dysfunction. As a protein modification related to homocysteine, homocysteinylation can promote the occurrence and development of cerebral atherosclerosis by promoting oxidation, changing lipid function and destroying vascular endothelial function. This article reviews the role of homocysteinylation in cerebral atherosclerosis, and discusses the possibility of preventing cerebral atherosclerosis by homocysteinylation.
