Correlation between serum lipoprotein (a) and the severity of white matter hyperintensities in middle-aged and elderly people in the community
10.3760/cma.j.issn.1673-4165.2023.04.004
- VernacularTitle:血清脂蛋白(a)与社区中老年人脑白质高信号严重程度的相关性
- Author:
Cunsheng WEI
1
;
Xingyue DU
;
Xiaorong YU
;
Yanhua YU
;
Junrong LI
;
Xuemei CHEN
Author Information
1. 南京医科大学附属江宁医院神经内科，南京 211100
- Keywords:
Cerebral small vessel diseases;
White matter;
Lipoprotein (a);
Magnetic resonance imaging;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2023;31(4):259-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum lipoprotein (a) [LP(a)] and the severity of white matter hyperintensities (WMHs) in the middle-aged and elderly people in the community.Methods:Consecutive middle-aged and elderly residents residing in the community underwent physical examinations in the Affiliated Jiangning Hospital of Nanjing Medical University from June 2016 to August 2021 were retrospectively collected. Fasting venous blood was collected on the next day of admission to detect the level of Lp(a). During hospitalization, cranial MRI examination was performed and the severity of WMHs was graded using the Fazekas visual scoring method. Ordinal multivariate logistic regression analysis was used to determine independent related factors for the severity of WMHs.Results:A total of 1 752 patients were included in the analysis. There were 969 males (55.31%) and 783 females (44.69%). Their age was 66.18±10.32 years old. There were 1 167 patients (66.61%) in the mild WMHs group, 407 (23.23%) in the moderate WMHs group, and 178 (10.16%) in the severe WMHs group. Ordinal multivariable logistic regression analysis showed that after adjusting for confounding factors, a higher serum Lp(a) level was independently related to the severity of WMHs (with the first quartile as a reference, the third quartile: odds ratio 1.441, 95% confidence interval 1.050-1.976, P=0.023; the fourth quartile: odds ratio 1.717, 95% confidence interval 1.252-2.354, P=0.001). Conclusion:Serum Lp(a) is independently correlated with the severity of WMHs.
