Encephalo-duro-arterio-synangiosis for intracranial arterial steno-occlusive disease: a retrospective case series study of 40 cases
10.3760/cma.j.issn.1673-4165.2023.03.005
- VernacularTitle:脑–硬膜–动脉血管融通术治疗颅内动脉粥样硬化狭窄闭塞性疾病：40例回顾性病例系列研究
- Author:
Bin REN
1
;
Huaiyu TONG
;
Mou GAO
;
Wei RAO
;
Yakun CHEN
;
Lian DUAN
;
Jianning ZHANG
Author Information
1. 中国人民解放军总医院第一医学中心神经外科医学部，北京 100853
- Keywords:
Intracranial arterial diseases;
Intracranial arteriosclerosis;
Cerebral revascularization;
Ischemic stroke;
Ischemic attack, transient;
Treatment outcome
- From:
International Journal of Cerebrovascular Diseases
2023;31(3):187-191
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of encephalo-duro-arterio-synangiosis (EDAS) for intracranial atherosclerotic steno-occlusive disease (ICASD).Methods:Patients with symptomatic ICASD received EDAS treatment in the Department of Neurosurgery, the PLA General Hospital from January 2018 to January 2019 were retrospectively included. The baseline information, perioperative complications, primary endpoint events, and changes in modified Rankin Scale (mRS) scores before and after surgery were collected. The primary endpoint event was any stroke/death that occurred within 30 d after enrollment. The secondary endpoint events were any stroke/death, non-stroke bleeding (subdural or epidural bleeding), and clinical functional improvement after 30 d. The clinical functional improvement was defined as a decrease of ≥1 in the mRS score compared to before surgery.Results:A total of 40 patients were included, including 30 males and 10 females, aged 53.9±8.6 years old. The clinical symptoms were mainly limb weakness and dizziness. One case of ischemic stroke and one case of hemorrhagic stroke occurred during the perioperative period. The primary endpoint event incidence was 2.5%. The patients were followed up for 49.75±2.99 months after surgery. One patient died of cerebral hemorrhage 31 months after surgery, and one patient developed acute ischemic stroke 35 months after surgery. The postoperative mRS scores of 34 patients decreased compared to before surgery, and the clinical function improvement rate was 85%. The mRS score increased in 2 cases after surgery compared to before surgery and 4 cases had no change.Conclusion:EDAS can improve the clinical function of patients with symptomatic ICASD and reduce the incidence of long-term stroke.
