Correlation between serum albumin and outcomes of successful recanalization after mechanical thrombectomy in patients with anterior circulation ischemic stroke
10.3760/cma.j.issn.1673-4165.2023.03.002
- VernacularTitle:血清白蛋白与血管内机械血栓切除术后血管成功再通的前循环缺血性卒中患者转归的相关性
- Author:
Hao LU
1
;
Fei WANG
;
Yongnan HAO
;
Dongxu YANG
;
Yanan CHEN
;
Qiang GUO
Author Information
1. 济宁医学院附属医院急诊卒中科，济宁 272000
- Keywords:
Ischemic stroke;
Endovascular procedures;
Thrombectomy;
Serum albumin;
Hypoalbuminemia;
Treatment outcome;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2023;31(3):168-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum albumin and hypoalbuminemia (HA) and the outcome after endovascular mechanical thrombectomy (EMT) in patients with stroke caused by acute anterior circulation large vessel occlusion.Methods:Stroke patients caused by acute anterior circulation large vessel occlusion received EMT treatment at the Department of Emergency Stroke, the Affiliated Hospital of Jining Medical University from June 2020 to August 2022 were retrospectively included. The demographic information, baseline clinical data, endovascular treatment parameters, and clinical outcomes of the patients were collected. HA was defined as serum albumin <35 g/L within 24 h of admission, and poor outcome was defined as the modified Rankin Scale score >2 at 90 d after onset. Multivariate logistic regression analysis was used to identify the independent influencing factors for poor outcomes. Results:A total of 177 patients were included, with a median age of 66 years, and 126 (71.19%) were males. Thirty-nine patients (22.03%) had HA, and 119 (67.23%) had poor outcomes. The proportion of pulmonary infection in the HA group was significantly higher than that in the non-HA group ( P<0.05). Multivariate logistic regression analysis showed that lower serum albumin (odds ratio [ OR] 4.102, 95% confidence interval [ CI] 1.316-16.451; P=0.028), postprocedural neurological deterioration ( OR 6.326, 95% CI 1.263-48.318; P=0.042) and pulmonary infection ( OR 5.873, 95% CI 1.028-24.452; P=0.018) were significantly independently associated with the poor outcomes. Conclusions:The HA group has a higher incidence of postprocedural pulmonary infection. Lower serum albumin, postprocedural neurological deterioration and pulmonary infection are the independent risk factors for the poor outcomes in patients with anterior circulation ischemic stroke who had successful recanalization after EMT.
