Pathogenesis of cerebral small vessel disease
10.3760/cma.j.issn.1673-4165.2023.02.012
- VernacularTitle:脑小血管病的发病机制
- Author:
Huimin ZHOU
1
;
Yan WANG
;
Fangxing SONG
;
Zhongrui YAN
Author Information
1. 济宁医学院，济宁 272067
- Keywords:
Cerebral small vessel diseases;
Brain ischemia;
Blood-brain barrier;
Endothelium, vascular;
Inflammation;
Cerebral amyloid angiopathy
- From:
International Journal of Cerebrovascular Diseases
2023;31(2):146-150
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral small vessel disease (CSVD) is an important cause of ischemic stroke and vascular dementia, which brings heavy burden to families and society. The prevention and treatment of CSVD has always been a research hotspot, but its pathogenesis is still not completely clear. This article reviews the pathogenesis of CSVD, including chronic cerebral hypoperfusion, blood-brain barrier dysfunction, vascular endothelial dysfunction, interstitial fluid reflux disorder, inflammatory response, and genetic factors, in order to provide more sufficient theoretical basis for early intervention and treatment of CSVD.
