Mechanism of white matter hyperintensity involved in hemorrhagic transformation after intravenous thrombolysis
10.3760/cma.j.issn.1673-4165.2022.12.010
- VernacularTitle:脑白质高信号参与静脉溶栓后出血性转化的相关机制
- Author:
Ying JIA
1
;
Xinxin GUO
;
Yan GAO
;
Yingru WANG
;
Jiayi NIU
;
Qianqian LI
;
Qian SHI
;
Shanshan YANG
Author Information
1. 哈尔滨医科大学附属第一医院神经内科，哈尔滨 150000
- Keywords:
Stroke;
Brain ischemia;
Thrombolytic therapy;
White matter;
Cerebral hemorrhage;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2022;30(12):939-943
- CountryChina
- Language:Chinese
-
Abstract:
Cerebrovascular disease is a common disease that seriously endangers the health of Chinese people. White matter hyperintensities (WMHs) are the most common in elderly patients. Intravenous thrombolysis is currently the most effective drug treatment for acute ischemic stroke. Hemorrhagic transformation (HT) is the most common serious complication after intravenous thrombolysis in patients with acute ischemic stroke. The destruction of blood-brain barrier in patients of WMHs can increase the risk of HT after intravenous thrombolysis. Matrix metalloproteinases and S100B jointly participate in the destruction process of blood-brain barrier in WMHs and HT after intravenous thrombolysis. At present, the pathogenesis of WHM and HT is not completely clear, and whether mild and moderate WMHs will aggravate HT is still controversial. Nevertheless, WMHs are still the independent risk factor for HT.
