Mitophagy: a potential therapeutic target for ischemic stroke
10.3760/cma.j.issn.1673-4165.2022.11.013
- VernacularTitle:线粒体自噬：缺血性卒中的潜在治疗靶点
- Author:
Li ZHOU
1
;
Yongdan CUN
;
Simei ZHANG
;
Xichen YANG
;
Chengcai ZHANG
;
Yaju JIN
;
Pengyue ZHANG
Author Information
1. 云南中医药大学第二临床医学院针灸推拿防治脑病重点实验室，昆明 650500
- Keywords:
Stroke;
Brain ischemia;
Reperfusion injury;
Mitophagy;
Mitochondria;
Neuroprotection
- From:
International Journal of Cerebrovascular Diseases
2022;30(11):864-869
- CountryChina
- Language:Chinese
-
Abstract:
After ischemic stroke, the key to reduce the mortality and disability rate is to restore the blood supply of brain tissue as soon as possible. However, the cerebral ischemia-reperfusion injury (CIRI) caused by blood flow restoration is also an important cause of brain tissue structural damage and dysfunction. Studies in recent years have shown that the activation of mitophagy at CIRI stage can reduce the volume of cerebral infarction and protect neurons from CIRI, while excessive or insufficient mitophagy can aggravate CIRI. This suggests that inducing moderate mitophagy may be a potential therapeutic target for neuroprotection after stroke. However, the neuroprotective mechanism of mitophagy has not yet been fully elucidated. This article reviews the neuroprotective mechanism and potential application of mitophagy in stroke, and discusses some problems of mitophagy as a therapeutic target for stroke.
