Role of CCAAT/enhancer binding protein β in acute cerebral ischemia
10.3760/cma.j.issn.1673-4165.2022.10.013
- VernacularTitle:CCAAT/增强子结合蛋白β在急性脑缺血中的作用
- Author:
Tieshi ZHU
1
;
Kongping LI
;
Xialin ZUO
;
Xiaohui CHEN
;
En XU
Author Information
1. 广州医科大学神经科学研究所，广州医科大学附属第二医院神经内科，广州 510260
- Keywords:
Brain ischemia;
CCAAT-enhancer-binding protein-β;
Apoptosis;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2022;30(10):792-796
- CountryChina
- Language:Chinese
-
Abstract:
CCAAT/enhancer binding protein β (C/EBPβ), a transcriptional factor of the basic-leucine zipper family, can regulate the transcription activity of downstream target genes. After acute cerebral ischemia, the activity of C/EBPβ changes, and participates in the process of cerebral ischemia injury by regulating neuronal apoptosis and inflammation. This article reviews the molecular biological characteristics of C/EBPβ and its expression changes and role in acute cerebral ischemia, providing a basis for developing new neuroprotective drugs for acute cerebral ischemia using C/EBPβ as therapeutic target.
