Caludin-5: target of regulating blood brain barrier in the treatment of ischemic stroke
10.3760/cma.j.issn.1673-4165.2022.09.012
- VernacularTitle:密封蛋白-5：调控血脑屏障治疗缺血性卒中的靶点
- Author:
Zhiyu SUN
1
;
Qingying LI
;
Zhongling ZHANG
Author Information
1. 哈尔滨医科大学附属第一医院神经内科，哈尔滨 150001
- Keywords:
Stroke;
Brain ischemia;
Blood-brain barrier;
Tight junctions;
Claudin-5
- From:
International Journal of Cerebrovascular Diseases
2022;30(9):706-709
- CountryChina
- Language:Chinese
-
Abstract:
The blood brain barrier (BBB) is a physical and metabolic barrier that maintains central nervous system homeostasis and protects brain tissues from potentially hazardous circulating substances. This article reviews the biological characteristics of caludin-5 during cerebral ischemia, its role in BBB integrity and permeability, as well as the research progress of related drug therapy based on calludin-5.
