Advances in gonadal damage in children induced by hematopoietic stem cell transplantation
10.3760/cma.j.issn.1673-4408.2023.07.010
- VernacularTitle:儿童造血干细胞移植致性腺损伤研究进展
- Author:
Xiao DONG
1
;
Fengyan TIAN
Author Information
1. 郑州大学第一附属医院儿科 450052
- Keywords:
Children;
Hematopoietic stem cell transplantation;
Gonads;
Puberty;
Fertility preservation
- From:
International Journal of Pediatrics
2023;50(7):468-472
- CountryChina
- Language:Chinese
-
Abstract:
Hematopoietic stem cell transplantation(HSCT), as a technique to reconstruct normal hematopoietic and immune function, has become a treatment option for a variety of malignant and non-malignant diseases in children.With the development of medical technology, the long-term survival rate of children after HSCT is significantly improved.At the same time, there is more concern and awareness about the late effects of HSCT.As one of the endocrine complications with the highest incidence in children after HSCT, gonadal damage leads to sex hormone secretion disorder, adolescent dysplasia, and infertility in adulthood, which has a serious influence on children′s mental health and quality of life.Therefore, it is helpful to reduce the psychological and economic burden on children and their families by understanding its potential mechanism, evaluating risk factors, screening early warning and recovery markers of gonadal function as well as taking corresponding preventive and protective measures.
