Advances in the fluid management strategies of pediatric acute respiratory distress syndrome
10.3760/cma.j.issn.1673-4408.2023.07.003
- VernacularTitle:儿童急性呼吸窘迫综合征液体管理策略的研究进展
- Author:
Yunrong CHEN
1
;
Jing LI
;
Lan HU
Author Information
1. 重庆医科大学附属儿童医院重症医学科 国家儿童健康与疾病临床医学研究中心 儿童发育疾病研究教育部重点实验室 儿童发育重大疾病国家国际科技合作基地 儿科学重庆市重点实验室 400014
- Keywords:
Pediatric acute respiratory distress syndrome;
Fluid management;
Sub-phenotype
- From:
International Journal of Pediatrics
2023;50(7):439-442
- CountryChina
- Language:Chinese
-
Abstract:
Pediatric acute respiratory distress syndrome(PARDS)is a pulmonary inflammation syndrome caused by a variety of proinflammatory factors induced by many causes, which is mainly characterized by noncardiogenic pulmonary edema.The main pathophysiological feature is the destruction of the integrity of the alveolar capillary membrane, and the loss of the alveolar epithelial-endothelial barrier function.In the PARDS′s clinical practice, the mainstay of the treatment is supportive.Although there is still no clear definition and general consensus or guidelines, appropriate liquid therapy is an important part of non-ventilatory treatment measures.Proper fluid management strategy is helpful to improve pulmonary edema, maintain normal circulatory perfusion, prevent functional failure of important organs and improve the prognosis of patients.According to volume status, implementing the goal-oriented and phased differentiated fluid management strategy is significant for the therapy of PARDS patients.However, the effects of fluid strategy management according to PARDS phenotypes remain to be evaluated.
