Two Cases of Allergic Reactions to Mesna which Imitate Malar Rash.
- Author:
Jeong Cheol SEO
1
;
Sang Cheol BAE
;
Seung Cheol SHIM
;
Tae Hwan KIM
;
Jae Bum JUN
;
Sung Soo JUNG
;
In Hong LEE
;
Dae Hyun YOO
;
Seong Yoon KIM
Author Information
1. Eulji University.
- Publication Type:Case Report
- Keywords:
Malar rash;
Mesna;
Cyclophosphamide;
Systemic lupus erythematosus
- MeSH:
Acrolein;
Alkylating Agents;
Cyclophosphamide;
Cystitis;
Drug Therapy;
Exanthema*;
Flushing;
Humans;
Hypersensitivity*;
Lupus Erythematosus, Systemic;
Mesna*
- From:The Journal of the Korean Rheumatism Association
2000;7(2):196-199
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hemorrhagic cystitis is potentially life-threatening sequellae of chemotherapy using oxazaphosphorine alkylating agents (cyclophosphamide and ifosfamide). Mesna contains a sulfhydryl group that is believed to bind acrolein within the urinary collecting system and reduce the hemorrhagic cystitis without affecting the chemotherapeutic potential. To date, about thirty cases of hypersensitivity or allergic reactions of the delayed and urticarial type associated with mesna have been reported. We reported two patients with systemic lupus erythematosus who developed facial rash and flushing associated with mesna which imitate malar rash.
