Progress of pendrin in airway epithelia
10.3760/cma.j.issn.1673-4408.2023.06.005
- VernacularTitle:气道上皮中pendrin的研究进展
- Author:
Kang ZHU
1
;
Wenyan LI
;
Gen LU
Author Information
1. 广州市妇女儿童医疗中心呼吸科 510623
- Keywords:
Pendrin;
Anion transporter;
Airway epithelia;
Bronchial asthma;
Airway defense
- From:
International Journal of Pediatrics
2023;50(6):378-382
- CountryChina
- Language:Chinese
-
Abstract:
Pendrin is an electroneutral anion exchanger transporter, residing in the apical region of airway epithelium cells.It is responsible for the reabsorption of chloride(Cl -) and the exchange of bicarbonate(HCO 3－)or thiocyanate(SCN -) to the lumen.It is mainly involved in regulating the pH and thickness of airway surface liquid(ASL), mucin secretion, and airway defense, which is of great significance for maintaining the stability of the airway surface microenvironment.The expression of pendrin is significantly up-regulated in bronchial asthma, which is closely related to the pathological processes of the lung in bronchial asthma, such as airway hyperresponsiveness, neutrophil infiltration, and increased mucin secretion.Inhibiting the function of pendrin may be a new target for the treatment of bronchial asthma.
