Progress on the relationship between hyperoxia exposure and renal development in premature infants
10.3760/cma.j.issn.1673-4408.2023.06.004
- VernacularTitle:早产儿高氧暴露与肾脏发育关系的研究进展
- Author:
Huan DENG
1
;
Yaru ZHANG
;
Yao GUO
;
Kai YOU
Author Information
1. 中国医科大学附属盛京医院儿科，沈阳 110004
- Keywords:
Infant, premature;
High oxygen content;
Kidney development;
Kidney damage
- From:
International Journal of Pediatrics
2023;50(6):374-377
- CountryChina
- Language:Chinese
-
Abstract:
Oxygen therapy is a common therapeutic method to improve oxygenation of premature infants, but long-term exposure to high oxygen can cause damage to immature organs and abnormal development.In addition to bronchopulmonary dysplasia and retinopathy, high oxygen levels will increase the risk of chronic kidney disease and hypertension in adulthood.High oxygen exposure can lead to kidney damage and developmental abnormalities in premature infants, including reduced number and increased volume of glomeruli, renal cell apoptosis, and abnormal development of renal tubules.The mechanism may be related to abnormal signaling pathways related to renal development.This article reviews the relationship between hyperoxia and kidney development and the possible mechanism of kidney disease, in an attempt to provide theoretical reference for early clinical intervention.
