An Isolated AST Elevation due to Macroenzyme Formation.
- Author:
Hye Ok KIM
;
Choon Sik CHOI
;
Joo Hyun SOHN
;
Young Woo SOHN
;
Dong Soo HAN
;
Yong Cheol JEON
;
Ho Soon CHOI
;
Joon Soo HAHM
;
Min Ho LEE
;
Kyung Nam PARK
;
Choon Suhk KEE
;
Duck An KIM
- Publication Type:Original Article
- Keywords:
Aspartate aminotransferase (AST);
Macroenzyme
- MeSH:
Aspartate Aminotransferases;
Brain;
Chemistry;
Electrophoresis;
Erythrocytes;
Heart Diseases;
Hepatocytes;
Humans;
Immunoglobulins;
Kidney;
Leukocytes;
Liver Diseases;
Lung;
Muscular Diseases;
Necrosis;
Pancreas
- From:The Korean Journal of Hepatology
1999;5(1):50-54
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Serum aspartate aminotransferase (AST) is a common enzyme for the evaluation of the hepatic, muscular and cardiac diseases and is produced also at kidney, brain, pancreas, lung, leukocytes, erythrocytes, etc. The elevation of its activity is usually caused by the necrosis of hepatocytes when there are not muscular injuries or myopathies. Recently, it is found that AST can exist as a macroenzyme by forming a complex with an immunoglobulin and this complex is erroneously considered to indicate the presence of liver disease as a result of elevation of AST activity on routine blood chemistry analysis. We experienced the patient with isolated AST elevation due to the formation of AST-mmunoglobulin complex confirmed by AST isoenzyme electrophoresis (EP).
