Advances in intestinal flora metabolites deoxycholic acid and digestive diseases in children
10.3760/cma.j.issn.1673-4408.2023.04.011
- VernacularTitle:肠道菌群代谢物脱氧胆酸与儿童消化系统疾病研究进展
- Author:
Caihong LIANG
1
;
Yongkun HUANG
Author Information
1. 昆明医科大学第一附属医院儿科 650032
- Keywords:
Intestinal flora metabolites;
Deoxycholic acid;
Non-alcoholic fatty liver disease;
Inflammatory bowel disease;
Irritable bowel syndrome
- From:
International Journal of Pediatrics
2023;50(4):267-271
- CountryChina
- Language:Chinese
-
Abstract:
It is the hotspot that studying the interplay and mechanism between intestinal flora metabolites and diseases.Deoxycholic acid, one of the intestinal flora metabolites, is one of the most abundant secondary bile acids in human intestinal tract, which is corelated with many diseases, while the mechanisms remain unclear.The imbalance of deoxycholic acid is connected with the intestinal flora disorder and high fat diet, which could result in several immunoreaction and inflammatory reaction.In this review, the interaction between deoxycholic acid and digestive diseases in children, such as non-alcoholic fatty liver disease, inflammatory bowel disease and irritable bowel syndrome, is discussed to explore their related mechanism, so as to clarify the direction of further study on the influence of intestinal microbiota metabolites deoxycholic acid on the human body.
