Progress of T lymphocytes in the pathogenesis of bronchopulmonary dysplasia in premature infants
10.3760/cma.j.issn.1673-4408.2023.04.010
- VernacularTitle:T细胞在早产儿支气管肺发育不良发病机制中的研究进展
- Author:
Mengzhao LI
1
;
Xueping ZHU
Author Information
1. 苏州大学附属儿童医院新生儿科 215025
- Keywords:
Infant, premature;
Bronchopulmonary dysplasia;
T lymphocytes;
Homeostatic proliferation;
Inflammation
- From:
International Journal of Pediatrics
2023;50(4):262-266
- CountryChina
- Language:Chinese
-
Abstract:
Bronchopulmonary dysplasia(BPD)is a severe complication in premature infants, and the pathogenesis remains complex, potentially involving pulmonary inflammatory injury and faulty reparative response.T-cell immaturity in preterm neonates and the upregulation of related harmful regulatory genes, as well as the imbalance of T-cell homeostasis, have been reported to contribute significantly to the development of inflammatory diseases.Growing evidence suggests that alterations in the levels and functions of T cell subsets may participate in the development of BPD, serving as a new avenue for BPD prevention and treatment.Herein, we summarize recent advancements in understanding the role of T lymphocytes in the pathogenesis of BPD.
