Advances in neutrophil extracellular traps in bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4408.2023.04.009
- VernacularTitle:中性粒细胞胞外诱捕网在支气管肺发育不良中的研究进展
- Author:
Ziwei YU
1
;
Jing YIN
;
Yun QIAN
;
Shuping HAN
Author Information
1. 南京医科大学附属妇产医院（南京市妇幼保健院）儿科 210004
- Keywords:
Bronchopulmonary dysplasia;
Neutrophil extracellular traps;
Inflammation;
Premature infants
- From:
International Journal of Pediatrics
2023;50(4):257-261
- CountryChina
- Language:Chinese
-
Abstract:
Due to the development of neonatal intensive care, the survival rate of very preterm infants and very low birth weight infants has been significantly improved, and the incidence of bronchopulmonary dysplasia (BPD) has been obviously increasing year by year.The pathogenesis of BPD has not been clear, it is considered that inflammation is an important link in the occurrence and development of BPD at present.Neutrophils can use their neutrophil extracellular traps (NETs) to capture and kill pathogens and reduce inflammation, but excessive formation of NETs is easy to induce inflammatory imbalance, so as to damage normal cells or tissues and participate in the pathophysiological process of BPD.This paper reviews the structure, formation, function and regulatory role of NETs in BPD, and the targeted treatment strategies and potential research directions of NETs in BPD.
