Advances in diagnosis and treatment of non-neoplastic Epstein-Barr virus infection-related diseases in children
10.3760/cma.j.issn.1673-4408.2023.02.013
- VernacularTitle:儿童非肿瘤性EB病毒感染相关疾病诊治进展
- Author:
Jingyi REN
1
;
Liming CAO
Author Information
1. 南京医科大学附属儿童医院感染性疾病科 210008
- Keywords:
Children;
Epstein-Barr virus;
Non-neoplastic;
Diagnosis;
Treatment
- From:
International Journal of Pediatrics
2023;50(2):125-128
- CountryChina
- Language:Chinese
-
Abstract:
The infection rate of Epstein-Barr virus(EBV)in the population is as high as 95%.It is the first carcinogenic virus found by human beings.Children infected with EBV often cause non-neoplastic diseases, including infectious mononucleosis, chronic active EBV infection and hemophagocytic lymphohistiocytosis.Most of the diseases related to non-neoplastic EBV infection in children are self-limited diseases, and a few of them are complicated with serious complications or develop into neoplastic diseases.The pathogenesis of this kind of disease is complex, the condition is varied, and some children with gene defects have a poor prognosis.Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an effective treatment for refractory children.At the same time, the condition of some critically ill children is progressing rapidly, so it is very important to create the opportunity of allo-HSCT for such children.
