Role of 11-oxygenated androgens in the diseases of pediatric hyperandrogenism
10.3760/cma.j.issn.1673-4408.2023.02.006
- VernacularTitle:11-氧雄激素在儿童高雄激素血症相关疾病中的作用
- Author:
Wen RUAN
1
;
Tian LAN
;
Hui YAO
Author Information
1. 江汉大学医学院 430056
- Keywords:
11-oxygenated androgens;
Congenital adrenal hyperplasia;
Premature adrenarche;
Polycystic ovary syndrome
- From:
International Journal of Pediatrics
2023;50(2):96-99
- CountryChina
- Language:Chinese
-
Abstract:
Previously the diseases of pediatric hyperandrogenism were mainly diagnosed and evaluated by testing traditional androgens such as testosterone and androstenedione.However, clinical application has revealed a poor correlation between traditional androgens and the clinical manifestations of hyperandrogenism in some patients.It has been proposed that adrenal-derived 11-oxygenated androgen may also be involved in the course of this type of disease.The concentrations of 11-oxygenated androgen are elevated in androgen excess diseases, and they fulfill a variety of roles in human physiology and disease.This article discusses three aspects of the synthesis process, activity and content of 11-oxygenated androgen and their application in three androgen excess diseases: congenital adrenocortical hyperplasia, premature adrenarche and polycystic ovary syndrome, in order to help clinicians expand their clinical understanding and investigative thoughts on 11-oxygenated androgen.
