The mechanism of necrotizing enterocolitis-associated brain injury in neonates
10.3760/cma.j.issn.1673-4408.2023.01.006
- VernacularTitle:新生儿坏死性小肠结肠炎相关脑损伤的机制
- Author:
Sihang LI
1
;
Yongyan SHI
Author Information
1. 中国医科大学附属盛京医院儿内科，沈阳 110004
- Keywords:
Neonatal necrotizing enterocolitis;
Brain injury;
Inflammation;
Nutrition;
Brain-gut axis
- From:
International Journal of Pediatrics
2023;50(1):29-33
- CountryChina
- Language:Chinese
-
Abstract:
Necrotizing enterocolitis(NEC)is a serious gastrointestinal disease in the neonatal period and one of the main causes of death in premature infants.In recent years, with the advancement of neonatal intensive care, the survival rate of children with NEC has been improved.However, the survivors are often accompanied by poor neurological prognoses, such as periventricular leukomalacia, intraventricular hemorrhage, neurodevelopmental disorders.The pathogenesis of NEC has not been fully elucidated.This review discusses the factors that may influence NEC related brain injury, such as hypoxia and ischemia, inflammatory response, nutrition, and brain-gut axis, in order to provide an overview on the pathogenesis of NEC.
