Progress on cell differentiation and clinical application in neuroblastoma
10.3760/cma.j.issn.1673-4408.2023.01.005
- VernacularTitle:神经母细胞瘤的细胞分化和临床应用研究进展
- Author:
Yufeng JIANG
1
;
Yijin GAO
Author Information
1. 上海交通大学医学院附属上海儿童医学中心血液肿瘤科 200127
- Keywords:
Children;
Neuroblastoma;
Differentiation;
Differentiation therapy
- From:
International Journal of Pediatrics
2023;50(1):23-28
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma(NB)is the most common extracranial solid tumor in children.It is notable for highly heterogeneous and associated with tumor histologic classification and differentiation status, with ganglioneuroma representing fully mature and differentiated NB.Differentiation therapy reduces the adverse reactions caused by treatment without affecting normal cells and tissues by inducing the redifferentiation of NB cells, and has a good development prospect in the maintenance treatment of high-risk NB patients.Therefore, studying the key molecules and signaling pathways affecting NB differentiation is significant to further clarify the pathogenesis and improve the prognosis of neuroblastoma.This article reviews the important molecules related to NB cell differentiation, signaling pathways and the research progress of differentiation induction therapy.
