Progress on the role of the RARα regulating homeostatic synaptic plasticity in the pathogenesis of autism spectrum disorders
10.3760/cma.j.issn.1673-4408.2023.01.003
- VernacularTitle:RARα调控稳态突触可塑性在孤独症谱系障碍发病机制中的研究进展
- Author:
Hongmei HUANG
1
;
Yang MA
;
Ruiyun SHEN
;
Aimin LIANG
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院保健中心 100045
- Keywords:
Autism spectrum disorders;
Retinoic acid receptor α;
Homeostatic synaptic plasticity;
Mechanism
- From:
International Journal of Pediatrics
2023;50(1):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Autism spectrum disorders(ASD)is an important disease in children′s neuropsychic development disorder.The incidence rate is increasing now, which brings heavy burden to family and society.Functional studies of ASD related different single gene mutation models have showed that these overlapping phenotypes shared the common mechanism of the homeostatic synaptic plasticity impairment.Retinoic acid receptor α(RARα)regulate synaptic plasticity of the nervous system in both directions, through glutamate receptor subunit 1(GluR1)translation and RARα/mTOR signaling pathway, and affect the integration of sensory information and situational adaptive learning, and then affect the learning and memory function and neural synaptic signal network through the growth of dendritic spines.These researches suggest that RARα may work as a potential drug target for ASD, playing an important role in stable regulation of homeostatic synaptic plasticity, which is helpful for molecular typing accurate diagnosis and treatment of ASD.
