Progress in diagnosis and treatment of Epstein-Barr virus associated lymphoproliferative disease after solid organ transplantation in children
10.3760/cma.j.issn.1673-4408.2022.12.005
- VernacularTitle:儿童实体器官移植后EB病毒相关淋巴组织增生性疾病诊疗进展
- Author:
Jincheng ZHAO
1
;
Yijin GAO
Author Information
1. 上海交通大学医学院附属上海儿童医学中心血液肿瘤科 200127
- Keywords:
Children;
Post-transplant lymphoproliferative disease;
Epstein-Barr virus;
Solid organ transplantation
- From:
International Journal of Pediatrics
2022;49(12):815-818
- CountryChina
- Language:Chinese
-
Abstract:
Post transplant lymphoproliferative disease(PTLD)is one of the most serious malignant complication in children after solid organ transplantation.Immunosuppression after transplantation and Epstein-Barr virus infection are the two main reasons for the onset of PTLD.The diagnosis of the disease depends on pathology, which includes early lesions, monomorphic PTLD, polymorphic PTLD and Hodgkin′s lymphoma PTLD.The treatment includes reduction in immunosuppression, rituximab, chemotherapy, radiotherapy and surgery, etc.The selection of chemotherapy mainly depends on pathology.The advance in the management of PTLD will be reviewed in the manuscript.
